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Evaluation of repositories for sharing individual-participant data from clinical studies
Flexible Imputation of Missing Data. Oceanographic Analysis with R. Springer-Verlag, New York, October This package greatly simplifies oceanographic analysis by handling the details of discipline-specific file formats, calculations, and plots. Designed for real-world application and developed with open-source protocols, oce supports a broad range of practical work. Generic functions take care of general operations such as subsetting and plotting data, while specialized functions address more specific tasks such as tidal decomposition, hydrographic analysis, and ADCP coordinate transformation. In addition, the package makes it easy to document work, because its functions automatically update processing logs stored within its data objects.
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Metrics details. Data repositories have the potential to play an important role in the effective and safe sharing of individual-participant data IPD from clinical studies. We analysed the current landscape of data repositories to create a detailed description of available repositories and assess their suitability for hosting data from clinical studies, from the perspective of the clinical researcher. We assessed repositories that enable storage, sharing, discoverability, re-use of the IPD and associated documents from clinical studies using a pre-defined set of 34 items and publicly available information from April to June The indicators cover guidelines for data upload and data de-identification, data quality controls, contracts for upload and storage, flexibility of access, application of identifiers, availability of metadata, and long-term preservation.
Metrics details. One area of biomedical research where the replication crisis is most visible and consequential is clinical trials. Why do outcomes of so many clinical trials contradict each other? Why is the effectiveness of many drugs and other medical interventions so low? Why have prescription medications become the third leading cause of death in the US and Europe after cardiovascular diseases and cancer?