Molecular Biology of Human Cancers | SpringerLinkThe accumulation of knowledge associated with cancer biology continues to progress at a phenomenal rate; the electronic availability of research papers and news items makes access to new discoveries almost instantaneous. International meetings present opportunities to share scientific knowledge and develop collaborations, as well as fuelling competition between groups, to drive research forward. As a primary researcher or graduate student, the ability to adapt research projects to take advantage of new technological and scientific developments in the field of cancer biology requires a broad knowledge of subjects outside the primary areas of research. Similarly, an undergraduate or newcomer to the field must initially familiarise themselves with established principles before facing the daunting task of processing the vast amount of specialised knowledge available. The editors of The Molecular Biology of Cancer have identified the need for a book that assimilates critical aspects of cancer biology into a single resource to function as a reference tool and teaching aid applicable to both students and researchers alike. The book is divided into 18 chapters and a glossary.
3: Molecular basis of cancer part 1: changes in DNA underlie cancer
Book Review of "The Molecular Biology of Cancer" by Stella Pelengaris, Michael Khan (Editors)
You are currently using the site but have requested a page in the site. Would you like to change to the site? This capturing, comprehensive text, extensively revised and updated for its second edition, provides a detailed overview of the molecular mechanisms underpinning the development of cancer and its treatment. The highly readable presentation of a complex field, written by an international panel of researchers, specialists and practitioners, would provide an excellent text for graduate and undergraduate courses in the biology of cancer, medical students and qualified practitioners in the field preparing for higher exams, and for researchers and teachers in the field. For the teaching of cancer biology, special features have been included to facilitate this use: bullet points at the beginning of each chapter explaining key concepts and controversial areas; each chapter builds on concepts learned in previous chapters, with a list of key outstanding questions remaining in the field, suggestions for further reading, and questions for student review. All chapters contain text boxes that provide additional and relevant information. We should list the great reviews we got for first edition which are on the back of the 2 nd edition:.
The Molecular Biology of Cancer discusses the state of progress in the molecular biology of cancer. The book describes the effects of anticancer agents on nucleolar ultrastructure; the role of chromosomes in the causation and progression of cancer and leukemia; the replication, modification, and repair of DNA. The text also describes the metabolism and utilization of messenger RNA and other high molecular weight RNA and low molecular weight nuclear RNA; the characteristics, structures, and functions of nuclear proteins; and the process of protein synthesis. Nucleotides are reviewed with regard to its biosynthesis, inhibition of synthesis, and development of resistance to inhibitors. The book further tackles the biochemical mechanisms of chemical carcinogenesis; the oncogenic viruses; and the molecular correlation concept.
Over the last three decades, knowledge on the molecular biology of human cancers has vastly expanded. A host of genes and proteins involved in cancer development and progression have been defined and many mechanisms at the molecular, cellular and even tissue level have been, at least partly, elucidated. Insights have also been gained into the molecular mechanisms underlying carcinogenesis by chemical, physical, and biological agents and into inherited susceptibility to cancer. Accordingly, Part I of the book presents many of the molecules and mechanisms generally important in human cancers. Following an overview on the cancer problem, individual chapters deal with cancer genetics and epigenetics, DNA damage and repair, oncogenes, tumor suppressors, regulatory pathways in cancer, apoptosis, cellular senescence, tumor invasion, and metastasis.