Just me and 6000 rats pdf

Performed the experiments: MM. Analyzed the data: MM. A widely accepted theory explaining MLSP differences between species is the oxidative stress theory, which purports that reactive oxygen species ROS produced during mitochondrial respiration damage bio-molecules and eventually lead to the breakdown of regulatory systems and consequent death. Previous rat-pigeon studies compared only aspects of the oxidative stress theory and most concluded that the lower mitochondrial superoxide production of pigeons compared to rats was responsible for their much greater longevity. This conclusion is based mainly on data from one tissue the heart using one mitochondrial substrate succinate. Studies on heart mitochondria using pyruvate as a mitochondrial substrate gave contradictory results.

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