Biochemistry multiple choice questions and answers pdf

Biochemistry Interview Questions and Answers

A full-term female infant failed to gain weight and showed metabolic acidosis in the neonatal period. A physical examination at 6 months showed failure to thrive, hypotonia, small muscle mass, severe head lag, and a persistent acidosis pH 7. Blood lactate, pyruvate, and alanine were greatly elevated. Treatment with thiamine did not alleviate the lactic acidosis. Which of the following enzymes is most likely deficient in this patient? The symptoms are suggestive of Pyruvate dehydrogenase complex deficiency. Pyruvate dehydrogenase complex PDC deficiency PDCD is one of the most common neurodegenerative disorders associated with abnormal mitochondrial metabolism.