4. Global Approach to Biomedicine: Functional Genomics and ProteomicsFunctional genomics transcriptomics and proteomics is a global, systematic and comprehensive approach to identification and description of the processes and pathways involved in the normal and abnormal physiological states. The most applied methods of functional genomics today are DNA microarrays and proteomics methods, primarily two-dimensional gel electrophoresis coupled with mass spectrometry. Still, further systematic examination of differentially regulated genes and proteins in tissues and fluids in healthy vs. However, high-throughput technologies reflect biological fluctuations and methodological errors. Large amount of such different data challenges the performance and capacity of statistical tools and softwares available at the moment. Yet, further major developments in this field are pending and the intellectual investment will certainly result in clinical advances.
Applications of Genomics to Improve Public Health - Colleen McBride (2014)
Introduction to Genomic and Proteomic Data Analysis
Welcome to CRCPress. Please choose www. Your GarlandScience. The student resources previously accessed via GarlandScience. Resources to the following titles can be found at www.
Genomics can be broadly defined as the systematic study of genes, their functions, and their interactions. Analogously, proteomics is the study of proteins, protein complexes, their localization, their interactions, and posttranslational modifications. Some years ago, genomics and proteomics studies focused on one gene or one protein at a time. With the advent of high-throughput technologies in biology and biotechnology, this has changed dramatically. We are currently witnessing a paradigm shift from a traditionally hypothesis-driven to a data-driven research. The activity and interaction of thousands of genes and proteins can now be measured simultaneously.
NCBI Bookshelf. T he nature of biological inquiry and the norms of behavior in the scientific community have changed in the wake of the Human Genome Project HGP and the birth of proteomics. Complementing the traditional hypothesis-driven study of single genes or proteins is the option of studying many genes or proteins simultaneously. This sea change has occurred while both universities and industry have been aggressively seeking and defending intellectual property protection for discoveries, many of them well upstream of commercial application. In light of this changing environment, the National Institutes of Health NIH asked the National Academy of Sciences to study the granting and licensing of intellectual property rights on discoveries relating to genetics and proteomics and the effects of these practices on research and innovation. The committee reviewed the literature in the field, held several public sessions that included presentations by experts and stakeholders, and conducted a survey of how biomedical research scientists acquire, use, and experience intellectual property practices. Based on these sources of information, the committee drew conclusions and made recommendations in three broad areas that aim to ensure that the public investment in genomics and proteomics results in optimal public benefit:.